Coronavirus Epidemic Update 19: Treatment and Medication Clinical Trials

Coronavirus Epidemic Update 19: Treatment and Medication Clinical Trials

welcome to another MedCram lecture
update from the road I’m currently at a medical conference in Hawaii but will
continue to try to do these updates as they come up if we go to the world of
metre website we can see that they’ve breaking down the cases now into active
cases versus closed cases and you can see that they are still increasing
these numbers are printer represented we’ll get into more of that later then
we come to the graph of looking at the total cases outside of China and those
are still continuing to grow although it doesn’t appear as though it’s
logarithmic in nature we switch over to logarithmic we can see that it’s less
than linear if we look at daily cases excluding mainland China it seems to be
more sporadic with some days with up to 79 and the most recent at 22 and if we look
at these total death cases here going from the beginning of the year until
mid-february it’s quite obvious they’re still continuing to grow what’s unique
about this virus is that it has infected not just another mammalian species
specifically humans but as infected a species that can think act and retaliate
against this virus and that’s where we come to today and some of you have asked
us to talk about some of the medications that are being developed there’s a nice
article in nature that was published just a few days ago there’s more than 80
clinical trials currently launching to test chrony virus treatments and the big
thrust of this article is that there’s so many trials going on in China looking
at every single thing that you could possibly imagine see if it’s going to
work that there’s no standardization what
exactly is a recovery what is the definition of a recovery and if things
are not being blinded but things are being looked at is their nefarious work
they’re either intentionally or unintentionally so we’ll put a link to
this article in the description below but it talks about exactly what the
w-h-o is doing to try to standardize these trials to make sure that they can
be compared amongst each other and that the outcomes are true in nature and not
just to push medications or favorite drugs onto this coronavirus there are a
lot of medications and drugs for instance chloroquine phosphate which has
shown in vitro to have some pretty promising effects against the corona
virus it inhibits coronaviruses growth and currently this is being tested in
about ten hospitals and a hundred patients another drug that’s being
looked at is a VIP Rovere which is being looked at in a clinical trial of about
70 patients and of course the other one REM des aver and that is currently being
looked at in ten hospitals in Wuhan of course this one was developed for Ebola
and worked in vitro but it doesn’t seem to be working in vivo for Ebola but it’s
being used as a potential source of a medication to be used against this
corona virus another that they’re looking at is something
called convalescent plasma this is basically the plasma of patients who had
recovery from this corona virus so presumably there are antibodies that
have already been developed against the virus and if you take this plasma from
these donors and put it into patients who have severe infections of the corona
virus which all brings us to the big question
to really do the right research on this there has to be blind placebo randomized
controlled trials the question that I have and a lot of people have is if
people are saying already that things are looking promising that things are
getting better are they really conducting the right
kind of studies which leads me to the next thing I want to talk about that’s
what I do I’m not a epidemiologist I’m not an
administrator I don’t work for the WHL I’m just a pulmonary critical care
doctor takes care of patients so when patients are coming into the intensive
care unit and they’re crashing I’m the one that puts a central line in I’m the
one who puts the arterial line in we intubate the patient we do the
bronchoscopy so this virus has been a real interest for me so my full-time job
is taking care of patients and wanted to show you what’s been going on at least
what I’ve noticed in my practice in Southern California in the last month or
so I’ve seen personally at least three or four cases of influenza A let’s come
in and these patients have not done well recently had a young person come in who
went from just having reports of the flu to having severe pneumonia requiring
intubation within about two to three days and she went on to actually require
ECMO or ECMO which is where they do heart-lung bypass and what you’re
looking at here is a graph of the influenza positive tests by the CDC and
you can see the vast majority of these cases are h1n1 from 2009 which was a
very bad year we’re noticing that these patients have particularly bad cardiac
reactions to influenza I’ve seen a patient code and go a systolic
after being intubated I had another one who had ST segment elevation from a
biomarker Dittus the bottom line being is that this strain h1n1 is covered in
the annual vaccine that’s been covered since 2009 and so because I’m seeing
such a huge amount of this this is kind of a call-out to those who are
susceptible it’s not too late as you can see here the flu season still has some
weeks to burn through here to get vaccinated against this potentially
deadly strain of the influence a and for those of you who are
interested in our previous discussions where we talked about sleep boosting
your immune system please refer to our previous lectures and also to med cram
comm where we have numerous lectures on sleep insomnia sleep apnea and other
diseases that could be helpful in understanding thank you for joining us

100 thoughts on “Coronavirus Epidemic Update 19: Treatment and Medication Clinical Trials”

  1. Please subscribe and turn on alerts! … And we have many more videos at our website
    Quick links to our other videos on Coronavirus (COVID-19):
    – Coronavirus Epidemic Update 18: Cellphone Tracking, Increase in Hospitalizations, More Sleep Tips:

    – Coronavirus Epidemic Update 17: Spike in Confirmed Cases, Fighting Infections with Sleep (COVID-19):
    – Coronavirus Epidemic Update 16: Strengthening Your Immune Response to Viral Infections (COVID-19):
    – Coronavirus Epidemic Update 15: Underreporting, Prevention, 24 Day Incubation? (COVID19):
    – Coronavirus Epidemic Update 14: Hospital spread of infection, WHO allowed in China, N-95 masks:
    – Coronavirus Epidemic Update 13: Li Wenliang, nCoV vs Influenza, Dip in Daily Cases, Spread to Canada:
    – Coronavirus Epidemic Update 12: Unsupported Theories, Pneumonia, ACE2 & nCoV:
    – Coronavirus Epidemic Update 11: Antiviral Drugs, Treatment Trials for nCoV (Remdesivir, Chloroquine):
    – Coronavirus Epidemic Update 10: New Studies, Transmission, Spread from Wuhan, Prevention (2019-nCoV):
    – Coronavirus Epidemic Update 9: Fecal-Oral Transmission, Recovery vs Death Rate:
    – Coronavirus Outbreak Update 8: Travel Ban, Spread Outside of China, Quarantine, & MRSA:
    – Coronavirus Epidemic Update 7: Global Health Emergency Declared, Viral Shedding:
    – Coronavirus Outbreak Update 6: Asymptomatic Transmission & Incubation Period:
    – Coronavirus Update 5: Mortality Rate vs SARS / Influenza:
    – How Coronavirus Kills: Acute Respiratory Distress Syndrome (ARDS) & Treatment:
    – Coronavirus Update 3: Spread, Quarantine, Projections, & Vaccine:
    – Coronavirus Symptoms, Diagnosis, Treatment:
    – Coronavirus Outbreak – Transmission & Updates:

  2. Questions…..? How long does this virus remain in the host? Does the immune system eradicate the virus from the host? Or does the host remain a carrier (chronic)? .what is the time period of infectiousness for this virus?

  3. Just take an ounce of DMSO in 2 oz of cod liver oil a day. Kills everything, but maybe the virus dies before the host. Fight fire with fire.

  4. I'm hoping I can get some feedback… The last 2 years after our flu shots my husband and I both got rotten sick.. Like 2 weeks after. Is it just because the flu shot kills you're good bacteria and fighting abilities and during that time we caught the virus?

  5. Doc, let us imagine that someone has symtoms of flu/corona virus, they are hundreds of miles away from a hospital or treatment centre. is there a position a patient can be put in so that they can self drain any fluieds in the lungs, and also allowing maximum oxegen reaching the lungs.

  6. I would like to know where are the statistics for people who were vaccinated vs the ones not vaccinated! I guess talking about blind studies to be done is cool but we already have two populations available to study those vaccinated vs not.

  7. This is the only series about coronavirus updates that I'm following in YouTube. Was kind of worried my headset was busted because your voice sounds different but when I checked your previous video, they sounded okay. Did you change your microphone? Anyway, your videos are interesting enough to increase my sound quality tolerance, lol.

  8. When you get a chance, you might want to do an episode on the role age plays in getting infected, developing complications, and dying from this virus.

  9. I’m glad to hear they are trying different treatments, and they may be working. My family recently had influenza B, and it hit us hard and quick. I thought what was the point of getting the flu shot. But hearing influenza A is worse, I’m feel better now, that we were most likely protected. Thank you

  10. A friend of mine who lives in Wuhan said 3 of his co-workers parents have died from this. It is hard to hear of real people but comforting to hear your facts

  11. "I don't run anything or tell organizations how to operate, but when people are dying, I save em" thank you for your service, Dr. Seheult!

  12. What out for the next flu season. The 1918 Spanish flu came in with a whimper, the second year the roar could be heard around the world.

  13. Using convalescent plasma is a dangerous road to go down. FWIW I had H1N1 in 2009 due to travelling for work in MX. I was young & healthy yet was hospitalized with ARDS. I've never gotten the flu since then, and was recently contacted to take part of some study bc apparently H1N1 survivors gain a superior level of immunity that seems broadly effective across influenza strains. The patient stipend is quite a bit of money but the scheduling would be hard for me. I do encourage others to participate in those studies if they're able

  14. Thank you, Dr. Seheult, for talking about influenza A. I work with people who refuse to get a flu shot. It amazes me, as in every other aspect of their lives they are rational people! I don't get it. Anyway, we all out here in YouTubeville appreciate your sane and clear explanations without hyperbole, hype or histrionics!

  15. Well if YOU or your family or patients had COVID-19 are you saying you would prefer they be placed in blinded, randomizes controlled studies so half of them have the opportunity to develop pneumonia/organ failure/death??? Whaaaat?? This is a global health EMERGENCY/PANDEMIC, China does not have the LUXURY of randomizes trials!! Besides cloraquine has been around for 100 years!!! Put it in the WATER on the Diamond Princess! Withholding anything SAFE is tantamount to manslaughter.

  16. your delivery of this content is so well organized and clearly explained that it makes it easy to understand. Thanks for doing such an awesome job on such an important subject.

  17. We, (my son, wife and I) all got a nasty case of the flu a couple weeks ago in spite of getting our flu shots. My parents also got it a couple weeks before we did flying back to Seattle after visiting us and they also got their flu shots as well, for them it was even worse than for us but fortunately they recovered after a couple weeks. So maybe the flu is bad this year because the shots weren't so effective and not because people didn't get them?

  18. Thanks for taking the time to complete these updates. It's calming to have just the medical facts interpreted by a Doctor, without all the sensationalist extras from the News industry. It's greatly appreciated and generous of you to do this work! From an Australian.

  19. The WHO and specifically Soumya Swaminathan are wrong. The Chinese are not starting clinical trials; merely trying to save lives. The Chinese text clearly states that their clinicians are simply trying therapies in groups to see what comes up with the best results and that regulated clinical trials would begin as the Covid-19 abates. They also have very exacting definition of recovery. Can you imagine what would happen if 70,000 + patients stormed the hospital is of Southern California where you practice? The United States would completely fail. No privatized healthcare system can come close to handling the volume.

  20. 2 Peter 3:9 
    9 The Lord is not slack concerning his promise, as some men count slackness; but is longsuffering to us-ward, not willing that any should perish, but that all should come to repentance

    Exodus 15:26 
    26 And said, If thou wilt diligently hearken to the voice of the Lord thy God, and wilt do that which is right in his sight, and wilt give ear to his commandments, and keep all his statutes, I will put none of these diseases upon thee, which I have brought upon the Egyptians: for I am the Lord that healeth thee

  21. to be clear, this virus would we need to have eye protection on plus mask and gloves if coming in contact with a patient that might have this virus. I used to be a medic but now no longer in the medical field but a part of an emergency response team.

  22. Please stop calling it an epidemic, its quite clear that its a pandemic at this point. Underplaying the description of such a deadly disease is less than helpful.

  23. You're absolutely amazing for taking the time to create more content for your audience, regardless of your location, I respect you for that.

  24. 🇬🇧 Lots of people in the UK had awful flu this season. I was in bed for six days with temp of 101 and when my temp eventually went back to normal I got this awful phlegmy cough that took a month to go! As I'm 66 I never think the flu will kill me, but really worried about this virus.

  25. First of all, thank you so much for these uploads as well as for the rest of the topics. I've used your videos to revise as they are logical and explained in a way I can understand. Same goes for this series. My question is, how long can this virus survive on other objects?

  26. hey, i am currently in kenya and the first suspected case has just been reported. in my own opinion i believe the health care system here is not adequately prepared to handle covid 19.

  27. This virus seems on average to last 2 weeks after it has developed. So to apply Mr Spock logic, 2 weeks ago we had approx 8000 (approx) confirmed cases world wide, today we have 11,147 confirmed recovered!

  28. what i find strange is that the "WHO teams are drawing up a plan for a clinical-trial protocol that could simultaneously be run by clinicians around the world".

    I cannot believe these people do not already have one. This is not the first epidemic, What have they been doing all this time when we had SARS, MERS, EBOLA, HIV.
    so why was not one done then or before?

    i do not agree the trials would be in vain if they actually work the problem is if they do not work. For then one needs further analysis and there a standard approach is essential.
    Measures of clinical outcome are essential as the article cites

    "For example, a person’s stages of recovery or decline should be measured in the same way, regardless of the treatment being tested."

    but there was no evidence cited that shows this is not being done which again is a pity. Moreover, surely this should be done for all
    patients with the illness though more clerical staff would be needed to record the information.

  29. Google + FB could probably calculate everyone who could be possibly infected. They know where everyone is and was at all times.

  30. Remdesivir from Gilead company, the drugs who`s going to save china, its probably a very expensive antiviral med and not patented yet, but i`m confident it will save us from a pandemy!

  31. Yeah, it's infected an intelligent species… a virus that can potentially wipe out a species that is 1000000000000000x more intelligent…

  32. Thinking about this new plasma-based treatment, my concerns are 1) In a country that harvests organs from Falun Gong members, are the plasma 'donors' voluntary? 2) If it is an effective treatment, will any of this plasma go to ordinary folks?
    If it is indeed effective, the billionaires and elite will form an orderly queue, and no-one else will get a look-in.
    I wonder if that's why people are trapped in quarantine 'hospitals' – so survivors can't escape but can have their blood-plasma harvested. Grim.

  33. Does this coronavirus affect other mammals? If so, if it gets out into the countryside, that could be the collapse of wildlife globally.

  34. 70 years old, never had a flu shot, only had the flu once while visiting a doctor to get the only check up I had in the past 30 years. Went back for results, got a throat infection for 3 months. Next time I go to the doctor will be when I'm dead

  35. Hi I am an English man retired 72 years old and live in Jakarta Indonesia. I have lived and worked here for 17 years and have travelled around a lot so seen much of what Indonesia has infrastructure wise.
    I have been following the illness for some weeks and have got a little prepared in respect to sanitisation of my house and my wife's business as well as doing the basics of hand washing and refrain from shaking hands and kiss greetings.

    Many Chinese Indonesians usually go to China for their new year.

    I have been waiting for the illness to hit here and to-date it doesn't appear to have happened.

    Indonesia's major population generally mass in markets to buy food but do not generally have air-conditioning so are in temperatures of low to high 30's. this is different from Singapore and Malaysia who have more air-conditioning in normal daily living.

    The grape vine here would have shown if mass cases have occurred but that doesn't appear to be the case, local hospitals appear not to have cases not are they being over run.

    I am hoping that maybe that the higher temperatures here is an inhibit the virus spread particularly when you look at the cases that have occurred world wide.

    hope its not a pipe dream.


  36. Getting on one of these✈️there’s a good chance that you will be infected 🦠. All. Flights. Should have been grounded a month ago. Why. Keep spreading this virus 🦠if this virus was released to clear the streets of China it worked ???????????????????????????????????

  37. The 1918 Spainish flu had one hospital that claimed a zero death rate . The method they used was two enemas a day to clean out intestines where virus lives and starvation for some days except for pure orange juice which might have been the Vitamin C solution of the day . However that solution might have only stopped the first attack of the virus and no info on if it could stop the second wave cronite storm events that killed in minutes with blood bursting turning victims blue in colour in minutes

  38. Thank you for your sane voice in all the noise. You know you are getting it right when your number of viewers can fill a super bowl stadium 4 times over. Great job👍

  39. WOW!! I google Corona Virus 🦠 when it first spread. The informations was unclear, and fuzzy. This is great!! well informed from a Dr. that can get to the core of this new virus.
    I work in a medical field, it’s great to be informative about this new deadly virus. Thank you Doctor, great video!

  40. It appears that Sars-cov2/Covid-19 causes only mild symptoms in infants. infants are known to have underdeveloped immune systems. It makes me think that the virus causes the most damage by causing a severe allergic reaction in adults, often leading to organ failure.

    It appears that steroids and antiinflammatories would be of benefit.

  41. Because of how our doctors treat Lyme/Morgellons, I have less respect for them…correct that. It's a horror story, and there is no excuse.

  42. I'd also like to say thank you for your updates and being a wonderful doctor. My toddler had influenza a … he thankfully recovered without Tamiflu or medical intervention but I know it's a bad one. I'm curious has he not built an immunity of some sort against it?

  43. Admittedly, the corona virus is indeed horrifying, but in no way does the terror approach the absolute heartbreak, dread, angst, devastation and hopelessness the entire world feels (even the Amazon rain forest tribes have deep concern), about the trauma experienced by those who are existentially oppressed by improper pronouns. Let us all send healing energy to victims of incorrect pronoun oppression! May we prioritize our priorities? Can I get an Amen?

  44. With NEJM change in info on the Germany case. Where is there evidence of this virus passing from one person to another without symptoms. Also you said you are in Hawaii, well two Japanese tourist were in Maui for a period of time and when they returned to Japan they were positive for the virus. Be careful and keep up the great work.

  45. China trying to combat this alone brings the image of “Stepbrothers” to my mind, specifically the scene in witch the first pitch “Prestige World Wide”.

  46. 27jan20 Singapore reported 5 confirmed COVID-19 cases. 27jan20 US reported 5 confirmed COVID-19 cses. 31jan20 Singapore restricted travel from China. 02feb20 US restricted travel from China. 18feb20 Singapore reported 75 confirmed COVID-19 cases. 18feb20 US reported 15 confirmed COVID-19 cases. Why has the case count grown so much faster in tropical Singapore than it has in the US?

  47. Thank you for your informative videos. I have learned so much from them and you. I come from no medical background. Would you please talk about Nano Silver 10ppm and the possiblilties of it helping to prevent catching the virus (if at all). I recently purchased some in hopes of avoiding avoiding this possible pandemic and would like to hear your input. Thank you.

  48. Workers at sewage treatment plants are at elevated risk. Water droplets in the air above splashing sewage water is quite common at open air sewage treatment plants. Semi-treated sewage water is sprayed on beds of small stones to promote bacterial digestion of sewage particulates remaining in the water. I would not want to live downwind.

  49. "Its infected a species that can think act and relatiate against it" I like that. Thanks for keeping us updated on everything!

  50. Oh boy, I'll be in trouble. I have very severe asthma and have been tubed 7 times so far and it would have been more if I had said ok when they wanted to tube me. I try to fight as long as I'm awake.

  51. Enriched oxygen might make the virus
    Reproduce at a increasing rate as their virulence subsides at a corresponding rate burning themselves out! If not absorbed directly through bloodstream. The cassandra crossing.

  52. My dad had influenza and was on Tamiflu and he was transferred to a separate room in the hospital.
    I thank God we have the NHS in the UK …. they treated my dad exceptionally well and within 9 days he was back on his feet!
    I hope and pray for a cure to this coronavirus Ameen Ya Rabb

  53. I had a heathy, young mother die last week of influenza a last week so that you for bringing up the importance of vaccinations.

  54. To improve the immune system, have 3 teeth of garlic in the morning 2 before sleep and rest, the body will do the rest. And yeah, do not smoke.

  55. Thank you for making these videos! They are super informative and easy to follow! You also don’t use scare tactics like the media and it makes understanding this virus much more tolerable!

  56. Hello! Thank you for your research & knowledge! Please tell us if it's worth buying 1) disposable, and/or 2) non-disposable microporus hazemat suits. Thank you!

  57. How dare the corrupt WHO put a banner on someone actually giving facts, ty for all you are doing for the human race !!

  58. DEAR After conducting many innovative experiments, i found that CAMPHOR INHALERS may restrict this kind of problems,kindly ensure consider this….

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