A research team has leapfrogged their 'DNA bricks' technology by two orders of magnitude, enabling next-generation DNA bricks to self-assemble into three-dimensional nanostructures that are 100 times more complex than those created with existing methods. The study provides user-friendly computational tools to design DNA nanostructures with complex cavities (and possibly surfaces) that have the potential to serve as building components in numerous nanotechnological applications in medicine and engineering.